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Article

Association between eIF3α polymorphism and severe toxicity caused by platinum-based chemotherapy in non-small cell lung cancer patients.

British journal of clinical pharmacology - 1 Feb 2013

Xu Xiaojing, Han Lifang, Duan Li, Zhao Yingchun, Yang Huaping, Zhou Boting, Ma Rui, Yuan Ruixia, Zhou Honghao, Liu Zhaoqian

Abstract excerpt

AIM: Platinum-induced toxicity severely impedes successful chemotherapy in lung cancer patients. The nucleotide excision repair (NER) pathway is considered as one of the major factors contributing to platinum effects. Furthermore, genetic variances of the NER pathway influence platinum toxicity. eIF3α, over expressed in many malignancies, is an up-stream gene of NER and could regulate its activity. The purpose of...

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Identifiers

PMID: 22804784
DOI: 10.1111/j.1365-2125.2012.04379.x
PMCID: PMC3579266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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