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Article

A miR-15a related polymorphism affects NSCLC prognosis via altering ERCC1 repair to platinum-based chemotherapy.

Journal of cellular and molecular medicine - 1 Nov 2022

Xue Ping, Zhang Guopei, Zhang Hongchao, Cui Su, Zhang Liang, Yu Tao, Xiao Mingyang, Li Liuli, Lu Xiaobo

Abstract excerpt

Platinum-based chemotherapy is regarded as a preferential curative-intent option for non-small cell lung cancer (NSCLC), while the acquired drug resistance has become a major obstacle that limits its clinical application. Since the repair efficiency of tumour cells to platinum-DNA adducts plays a crucial role in chemotherapy resistance, we aimed to explore whether several meaningful polymorphisms of DNA repair...

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Identifiers

PMID: 36181289
DOI: 10.1111/jcmm.17566
PMCID: PMC9639052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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