Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes.

doi:10.3109/08916934.2010.509120

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Article

Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes.

Autoimmunity - 1 Mar 2011

Brorsson Caroline, Vaziri-Sani Fariba, Bergholdt Regine, Eising Stefanie, Nilsson Anita, Svensson Jannet, Lernmark Åke, Pociot Flemming

Abstract excerpt

We hypothesised that the correlation between autoantibody specificity for the ZnT8 Arg325Trp isoforms and the type 2 diabetes-associated rs13266634 may affect β-cell function at type 1 diabetes (T1D) onset. To study this, we tested 482 newly diagnosed diabetic probands and 478 healthy siblings from the Danish population-based T1D registry for autoantibodies to ZnT8 (ZnT8A) in addition to GAD65 and IA-2. The...

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PMID: 20836749
DOI: 10.3109/08916934.2010.509120

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