Article
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Molecular cell - 14 Dec 2012
Yang Weiwei, Xia Yan, Cao Yu, Zheng Yanhua, Bu Wen, Zhang Lin, You M James, Koh Mei Yee, Cote Gilbert, Aldape Kenneth, Li Yi, Verma Inder M, Chiao Paul J, Lu Zhimin
Abstract excerpt
Many types of human tumor cells have overexpressed pyruvate kinase M2 (PKM2). However, the mechanism underlying this increased PKM2 expression remains to be defined. We demonstrate here that EGFR activation induces PLCγ1-dependent PKCε monoubiquitylation at Lys321 mediated by RINCK1 ubiquitin ligase. Monoubiquitylated PKCε interacts with a ubiquitin-binding domain in NEMO zinc finger and recruits the cytosolic...
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