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Article

Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia.

Open biology - 1 Nov 2024

Garg Vranda, André Selina, Heyer Luisa, Kracht Gudrun, Ruhwedel Torben, Scholz Patricia, Ischebeck Till, Werner Hauke B, Dullin Christian, Engelmann Jacob, Möbius Wiebke, Göpfert Martin C, Dosch Roland, Geurten Bart R H

Abstract excerpt

Hereditary spastic paraplegias (HSPs) are a diverse set of neurological disorders characterized by progressive spasticity and weakness in the lower limbs caused by damage to the axons of the corticospinal tract. More than 88 genetic mutations have been associated with HSP, yet the mechanisms underlying these disorders are not well understood. We replicated the pathophysiology of one form of HSP known as spastic...

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Axons
Carrier Proteins
Demyelinating Diseases
Motor Neurons
Myelin Sheath

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spastic Paraplegia, Hereditary

Zebrafish Proteins

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Open in PubMed Open full text

Identifiers

PMID: 39503232
DOI: 10.1098/rsob.240100
PMCID: PMC11539067

Genes

ZFYVE26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia.PMID 39503232Read ↗

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