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Article

Targeting Id protein interactions by an engineered HLH domain induces human neuroblastoma cell differentiation.

Oncogene - 30 Apr 2009

Ciarapica R, Annibali D, Raimondi L, Savino M, Nasi S, Rota R

Abstract excerpt

Inhibitor of DNA-binding (Id) proteins prevent cell differentiation, promote growth and sustain tumour development. They do so by binding to E proteins and other transcription factors through the helix-loop-helix (HLH) domain, and inhibiting transcription. This makes HLH-mediated Id protein interactions an appealing therapeutic target. We have used the dominant interfering HLH dimerization mutant 13I to model the...

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Identifiers

PMID: 19330020
DOI: 10.1038/onc.2009.56

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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