Article
Donor and recipient cell surface colony stimulating factor-1 promote neointimal formation in transplant-associated arteriosclerosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2013
Hiroyasu Shungo, Chinnasamy Prameladevi, Hou Rong, Hotchkiss Kylie, Casimiro Isabel, Dai Xu-Ming, Stanley E Richard, Sibinga Nicholas E S
Abstract excerpt
OBJECTIVE: Transplant-associated arteriosclerosis manifests as progressive vascular neointimal expansion throughout the arterial system of allografted solid organs, and eventually compromises graft perfusion and function. Allografts placed in colony stimulating factor (CSF)-1-deficient osteopetrotic (Csf1(op)/Csf1(op)) mice develop very little neointima, a finding attributed to impaired recipient macrophage...
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