Article
Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children.
Cancer science - 1 Jun 2012
Haruta Masayuki, Arai Yasuhito, Watanabe Naoki, Fujiwara Yuiko, Honda Shohei, Ohshima Junjiro, Kasai Fumio, Nakadate Hisaya, Horie Hiroshi, Okita Hajime, Hata Jun-Ichi, Fukuzawa Masahiro, Kaneko Yasuhiko
Abstract excerpt
Epidemiological studies show that the incidence of Wilms tumor (WT) in East-Asian children is half of that in Caucasian children. Abnormalities of WT1, CTNNB1, WTX, and IGF2 were reported to be involved in Wilms tumorigenesis in Caucasians, although none of the studies simultaneously evaluated the four genes. WTX forms the β-catenin degradation complex; however, the relationship between WTX abnormality and CTNNB1...
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