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Article

Oxidative stress and protease dysfunction in the yeast model of Friedreich ataxia.

Free radical biology & medicine - 15 May 2007

Bulteau Anne-Laure, Dancis Andrew, Gareil Monique, Montagne Jean-Jacques, Camadro Jean-Michel, Lesuisse Emmanuel

Abstract excerpt

Friedreich ataxia has frequently been associated with an increased susceptibility to oxidative stress. We used the yeast (Saccharomyces cerevisiae) model of Friedreich ataxia to study the physiological consequences of a shift from anaerobiosis to aerobiosis. Cells lacking frataxin (Deltayfh1) showed no growth defect when cultured anaerobically. Under these conditions, a significant amount of aconitase was...

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PMID: 17448903
DOI: 10.1016/j.freeradbiomed.2007.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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