Article
Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.
Cell reports - 5 Jun 2018
Miranda Andre M, Herman Mathieu, Cheng Rong, Nahmani Eden, Barrett Geoffrey, Micevska Elizabeta, Fontaine Gaelle, Potier Marie-Claude, Head Elizabeth, Schmitt Frederick A, Lott Ira T, Jiménez-Velázquez Ivonne Z, Antonarakis Stylianos E, Di Paolo Gilbert, Lee Joseph H, Hussaini S Abid, Marquer Catherine
Abstract excerpt
The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We first tested whether SYNJ1 contributes to phenotypic variations in familial Alzheimer's disease (FAD) and show that SYNJ1 polymorphisms are associated with age of onset in both early- and late-onset human FAD cohorts. We then interrogated whether SYNJ1 levels could directly affect memory. We show that increased...
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