Article
Functional analysis of pneumococcal drug efflux pumps associates the MATE DinF transporter with quinolone susceptibility.
Antimicrobial agents and chemotherapy - 1 Jan 2013
Tocci Nadia, Iannelli Francesco, Bidossi Alessandro, Ciusa Maria Laura, Decorosi Francesca, Viti Carlo, Pozzi Gianni, Ricci Susanna, Oggioni Marco Rinaldo
Abstract excerpt
The pneumococcal chromosome encodes about 140 transporters, many of which are predicted to be involved in efflux. In order to critically evaluate pneumococcal efflux, a series of transporter mutants were constructed, and their phenotypes were assayed by disk diffusion, microdilution drug susceptibility testing (MIC testing), growth of cultures at sub-MIC concentrations, and phenotype microarray analysis. Mutants...
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