Article
Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Feb 2006
Marrer Estelle, Schad Karen, Satoh Andreas T, Page Malcolm G P, Johnson Maggie M, Piddock Laura J V
Abstract excerpt
The multidrug-resistant mutant Streptococcus pneumoniae M22 constitutively overexpresses two genes (patA and patB) that encode proteins homologous to known efflux proteins belonging to the ABC transporter family. It is shown here that PatA and PatB were strongly induced by quinolone antibiotics and distamycin in fluoroquinolone-sensitive strains. PatA was very important for growth of S. pneumoniae, and it could...
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