Article
The contribution of efflux pumps to quinolone resistance in Streptococcus pneumoniae clinical isolates.
International journal of medical microbiology : IJMM - 1 Jun 2007
Martinez-Garriga Blanca, Vinuesa Teresa, Hernandez-Borrell Jordi, Viñas Miguel
Abstract excerpt
Active efflux has been involved in fluoroquinolone resistance in Streptococcus pneumoniae. While only one efflux machinery has been well described (PmrA), the eventual existence of other pumps than PmrA has been suggested. The actual role of active quinolone efflux in producing ciprofloxacin resistance was examined by means of several methods. Strains HUB 2375 and HUB 3073 are clinical isolates resistant to...
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