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Characterizing the V516M penicillin-binding protein 2 (PBP2) mutation causing zidebactam resistance in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 5 Aug 2026

Sastre-Femenia Miquel Àngel, Gomis-Font Maria Antonia, Fernández-Muñoz Almudena, Salazar-Londoño Daniela, Moya Bartolome, Oliver Antonio

Abstract excerpt

The triple action of the diazabicyclooctane (DBO) zidebactam (antibacterial activity [penicillin-binding protein 2 {PBP2} inhibitor], β-lactam enhancement [synergy with PBP3 inhibitors], and β-lactamase inhibition [classes A and C]) provides a promising approach to overcome Pseudomonas aeruginosa resistance. However, PBP2 mutations (particularly V516M) are associated with resistance. Thus, we characterized the...

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Identifiers

PMID: 42294650
DOI: 10.1128/aac.00346-26
PMCID: PMC13435639

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