Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo

Abstract excerpt

BACKGROUND: The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT). METHODS: We used xenograft models of human cancer cells in immunocompromised mice, profiling the harvested tumors separately with species-specific probes and computationally analyzing the results. RESULTS:...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer Cells and Metastasis
• Share to Immune cells in cancer
• Share to Single-cell and spatial transcriptomics