Article
Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection.
BMC infectious diseases - 8 Sept 2013
Yang Jiezuan, He Jianqin, Huang Haijun, Ji Zhongkang, Wei Li, Ye Ping, Xu Kaijin, Li Lanjuan
Abstract excerpt
BACKGROUND: T cells are closely linked to the clinical manifestations of subjects with Mycobacterium tuberculosis (MTB) infection. T cell receptor beta variable (TCRBV) is a signal and indicative molecule on the membrane of T lymphocytes, reflecting the composition and specificity of T cells. The molecular profiles of TCRBV in peripheral blood mononuclear cells (PBMCs) and their subpopulations (CD4+ and CD8+ T...
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