Article
NAD(P)H:quinone oxidoreductase 1 (NQO1) P187S polymorphism and prostate cancer risk in Caucasians.
International journal of molecular sciences - 1 Jan 2012
Stoehr Christine G, Nolte Elke, Wach Sven, Wieland Wolf F, Hofstaedter Ferdinand, Hartmann Arndt, Stoehr Robert
Abstract excerpt
NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyses the reduction of quinoid compounds to hydroquinones, preventing the generation of free radicals and reactive oxygen. A "C" to "T" transversion at position 609 of NQO1, leading to a nonsynonymous amino acid change (Pro187Ser, P187S), results in an altered enzyme activity. No NQO1 protein activity was detected in NQO1(609)TT genotype, and low to intermediate...
Topics
- Aged
- Base Sequence
- Case-Control Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Polymorphism, Restriction Fragment Length