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Article

NAD(P)H:quinone oxidoreductase 1 (NQO1) P187S polymorphism and prostate cancer risk in Caucasians.

International journal of molecular sciences - 1 Jan 2012

Stoehr Christine G, Nolte Elke, Wach Sven, Wieland Wolf F, Hofstaedter Ferdinand, Hartmann Arndt, Stoehr Robert

Abstract excerpt

NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyses the reduction of quinoid compounds to hydroquinones, preventing the generation of free radicals and reactive oxygen. A "C" to "T" transversion at position 609 of NQO1, leading to a nonsynonymous amino acid change (Pro187Ser, P187S), results in an altered enzyme activity. No NQO1 protein activity was detected in NQO1(609)TT genotype, and low to intermediate...

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Identifiers

PMID: 23109831
DOI: 10.3390/ijms130910959
PMCID: PMC3472723

Genes

NQO1

Variants

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NAD(P)H:quinone oxidoreductase 1 (NQO1) P187S polymorphism and prostate cancer risk in Caucasians.PMID 23109831Read ↗

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Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer.Semantic proximity Read ↗

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Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis.Semantic proximity Read ↗

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