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Article

Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.

American journal of human genetics - 7 May 2015

Chan Yingleong, Salem Rany M, Hsu Yu-Han H, McMahon George, Pers Tune H, Vedantam Sailaja, Esko Tonu, Guo Michael H, Lim Elaine T, Franke Lude, Smith George Davey, Strachan David P, Hirschhorn Joel N

Abstract excerpt

Human height is a composite measurement, reflecting the sum of leg, spine, and head lengths. Many common variants influence total height, but the effects of these or other variants on the components of height (body proportion) remain largely unknown. We studied sitting height ratio (SHR), the ratio of sitting height to total height, to identify such effects in 3,545 African Americans and 21,590 individuals of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25865494
DOI: 10.1016/j.ajhg.2015.02.018
PMCID: PMC4570286

Genes

IGFBP3
TBX2

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