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Article

Malolactone strikes: K-Ras-G12D's Achilles' heel.

Trends in pharmacological sciences - 1 Jun 2024

Adamopoulos Christos, Papavassiliou Kostas A, Papavassiliou Athanasios G

Abstract excerpt

In a recent study in Nature Chemical Biology, Zheng et al. exploiting strain release by malolactone-based electrophiles designed a first-in-class covalent inhibitor that targets the elusive aspartate of the Kirsten rat sarcoma viral oncogene homolog (K-Ras)-G12D variant, which is highly prevalent in pancreatic cancer. The compound drastically inhibited oncogenic signaling and tumor growth in preclinical...

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Identifiers

PMID: 38653668
DOI: 10.1016/j.tips.2024.04.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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