Tumor cells that resist neutrophil anticancer cytotoxicity acquire a prometastatic and innate immune escape phenotype.

doi:10.1038/s41423-025-01283-w

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Article

Tumor cells that resist neutrophil anticancer cytotoxicity acquire a prometastatic and innate immune escape phenotype.

Cellular & molecular immunology - 1 May 2025

Szlachetko Jagoda Agnieszka, Hofmann-Vega Francisca, Budeus Bettina, Schröder Lara-Jasmin, Dumitru Claudia Alexandra, Schmidt Mathias, Deuss Eric, Vollmer Sebastian, Hanschmann Eva-Maria, Busch Maike, Kehrmann Jan, Lang Stephan, Dünker Nicole, Hussain Timon, Brandau Sven

Abstract excerpt

In the tumor host, neutrophils may exhibit protumor or antitumor activity. It is hypothesized that in response to host-derived or therapy-induced factors, neutrophils adopt diverse functional states to ultimately execute these differential functions. Here, we provide an alternative scenario in which the response of an individual tumor cell population determines the overall protumor versus antitumor outcome of...

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Topics

Neutrophils
Humans
Animals
Immunity, Innate
Matrix Metalloproteinase 9

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Line, Tumor

Phenotype

Mice

Tumor Escape

Leukocyte Elastase

Cytotoxicity, Immunologic

Epithelial-Mesenchymal Transition

Neoplasm Metastasis

Tumor Microenvironment

Female

Head and Neck Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40155451
DOI: 10.1038/s41423-025-01283-w
PMCID: PMC12041228

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