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Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens

25 Feb 2020

Abstract excerpt

Abstract Here, we developed an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to apoptosis by cisplatin (CDDP) treatment in vitro, as compared with their live counterparts. Among the multitude of proteins identified, some of them were represented as fragmented proteins in apoptotic tumor cells, and acted...

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PMID: 32099064
DOI: 10.1038/s42003-020-0811-x

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