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Article

The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance.

Cell cycle (Georgetown, Tex.) - 15 Nov 2012

Moskalev Alexey, Plyusnina Ekaterina, Shaposhnikov Mikhail, Shilova Lyubov, Kazachenok Alexey, Zhavoronkov Alexander

Abstract excerpt

There is a relationship between various cellular stress factors and aging. In earlier studies, we demonstrated that overexpression of the D-GADD45 gene increases the life span of Drosophila melanogaster. In this study, we investigate the relationship between D-GADD45 activity and resistance to oxidative, genotoxic and thermal stresses as well as starvation. In most cases, flies with constitutive and conditional...

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Identifiers

PMID: 23095639
DOI: 10.4161/cc.22545
PMCID: PMC3524218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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