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Article

Genomic instability in Gadd45a-deficient mice.

Nature genetics - 1 Oct 1999

Hollander M C, Sheikh M S, Bulavin D V, Lundgren K, Augeri-Henmueller L, Shehee R, Molinaro T A, Kim K E, Tolosa E, Ashwell J D, Rosenberg M P, Zhan Q, Fernández-Salguero P M, Morgan W F, Deng C X, Fornace A J

Abstract excerpt

Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exencephaly. Genomic instability was exemplified by aneuploidy, chromosome aberrations, gene amplification and centrosome amplification, and was accompanied by abnormalities in mitosis, cytokinesis and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10508513
DOI: 10.1038/13802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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