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Article

Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.

Metabolism: clinical and experimental - 1 Sept 2011

Ketterer Caroline, Müssig Karsten, Heni Martin, Dudziak Katarzyna, Randrianarisoa Elko, Wagner Robert, Machicao Fausto, Stefan Norbert, Holst Jens J, Fritsche Andreas, Häring Hans-Ulrich, Staiger Harald

Abstract excerpt

The functional knockout of the calcium-sensitive, nonselective cation channel TRPM5 alters glucose-induced insulin secretion and glucose tolerance. We hypothesized that genetic variation in the TRPM5 gene may contribute to prediabetic phenotypes, including pancreatic β-cell dysfunction. We genotyped 1798 white subjects at increased type 2 diabetes mellitus risk for 9 TRPM5 single nucleotide polymorphisms (namely,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21489577
DOI: 10.1016/j.metabol.2011.02.002

Genes

TRPM5

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