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Profiling of Age-Related Changes in the<i>Tibialis Anterior</i>Muscle Proteome of the mdx Mouse Model of Dystrophinopathy

1 Jan 2012

Abstract excerpt

X-linked muscular dystrophy is a highly progressive disease of childhood and characterized by primary genetic abnormalities in the dystrophin gene. Senescent mdx specimens were used for a large-scale survey of potential age-related alterations in the dystrophic phenotype, because the established mdx animal model of dystrophinopathy exhibits progressive deterioration of muscle tissue with age. Since the mdx...

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PMID: 23093855
DOI: 10.1155/2012/691641

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