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Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy

16 Sept 2016

Abstract excerpt

Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading to terminal muscle failure. We recently generated a novel genetically engineered pig model reflecting pathological hallmarks of human DMD better than the widely used mdx mouse. To get insight into the hierarchy of molecular derangements...

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PMID: 27634466
DOI: 10.1038/srep33362

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