Proteome analysis of the dystrophin‐deficient MDX diaphragm reveals a drastic increase in the heat shock protein cvHSP

Abstract excerpt

Duchenne muscular dystrophy is the most commonly inherited neuromuscular disorder in humans. Although the primary genetic deficiency of dystrophin in X-linked muscular dystrophy is established, it is not well-known how pathophysiological events trigger the actual fibre degeneration. We have therefore performed a DIGE analysis of normal diaphragm muscle versus the severely affected x-linked muscular dystrophy...

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