Article
Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy.
Molecular & cellular proteomics : MCP - 1 Dec 2020
van Westering Tirsa L E, Johansson Henrik J, Hanson Britt, Coenen-Stass Anna M L, Lomonosova Yulia, Tanihata Jun, Motohashi Norio, Yokota Toshifumi, Takeda Shin'ichi, Lehtiö Janne, Wood Matthew J A, El Andaloussi Samir, Aoki Yoshitsugu, Roberts Thomas C
Abstract excerpt
The absence of the dystrophin protein in Duchenne muscular dystrophy (DMD) results in myofiber fragility and a plethora of downstream secondary pathologies. Although a variety of experimental therapies are in development, achieving effective treatments for DMD remains exceptionally challenging, not least because the pathological consequences of dystrophin loss are incompletely understood. Here we have performed...
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