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Article

Genome editing abrogates angiogenesis in vivo

17 Jul 2017

Abstract excerpt

Angiogenesis, in which vascular endothelial growth factor receptor (VEGFR) 2 plays an essential role, is associated with a variety of human diseases including proliferative diabetic retinopathy and wet age-related macular degeneration. Here we report that a system of adeno-associated virus (AAV)-mediated clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from...

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PMID: 28740073
DOI: 10.1038/s41467-017-00140-3

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