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Article

An SMC ATPase mutant disrupts chromosome segregation in Caulobacter.

Molecular microbiology - 1 Dec 2011

Schwartz Monica A, Shapiro Lucy

Abstract excerpt

Accurate replication and segregation of the bacterial genome are essential for cell cycle progression. We have identified a single amino acid substitution in the Caulobacter structural maintenance of chromosomes (SMC) protein that disrupts chromosome segregation and cell division. The E1076Q point mutation in the SMC ATPase domain caused a dominant-negative phenotype in which DNA replication was able to proceed,...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21923769
DOI: 10.1111/j.1365-2958.2011.07836.x
PMCID: PMC3273039

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