Article
Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.
Open biology - 1 Sept 2012
Nakamura Takahiro, Pluskal Tomáš, Nakaseko Yukinobu, Yanagida Mitsuhiro
Abstract excerpt
Biosynthesis of coenzyme A (CoA) requires a five-step process using pantothenate and cysteine in the fission yeast Schizosaccharomyces pombe. CoA contains a thiol (SH) group, which reacts with carboxylic acid to form thioesters, giving rise to acyl-activated CoAs such as acetyl-CoA. Acetyl-CoA is essential for energy metabolism and protein acetylation, and, in higher eukaryotes, for the production of...
Topics
- Acetylation
- Amino Acid Sequence
- Cell Cycle Checkpoints
- Coenzyme A
- DNA Breaks, Double-Stranded
- DNA Repair
- DNA, Fungal
- Genes, Fungal
- Histone Acetyltransferases
- Histone Deacetylases
- Histones
- Mitosis
- Molecular Sequence Data