Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.

The Journal of biological chemistry - 29 Nov 2019

Reidman Sophie, Cohen Adiel, Kupiec Martin, Weisman Ronit

Abstract excerpt

The evolutionarily conserved TOR complex 1 (TORC1) activates cell growth and proliferation in response to nutritional signals. In the fission yeast Schizosaccharomyces pombe, TORC1 is essential for vegetative growth, and its activity is regulated in response to nitrogen quantity and quality. Yet, how TORC1 senses nitrogen is poorly understood. Rapamycin, a specific TOR inhibitor, inhibits growth in S. pombe only...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosol
Share to Asparagine
Share to Aspartate Aminotransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspartic Acid

Share to Mechanistic Target of Rapamycin Complex 1

Share to Nitrogen

Share to Schizosaccharomyces pombe Proteins

Share to Sirolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 31641022
DOI: 10.1074/jbc.RA119.010101
PMCID: PMC6885631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.PMID 31641022Read ↗

TORC1 signaling is governed by two negative regulators in fission yeast.Semantic proximity Read ↗

Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read ↗

Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.Semantic proximity Read ↗

Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.Semantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.Semantic proximity Read ↗

Opposite Effects of Tor1 and Tor2 on Nitrogen Starvation Responses in Fission YeastSemantic proximity Read ↗

Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast.Semantic proximity Read ↗

Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.Semantic proximity Read ↗

Target of Rapamycin (TOR) in Nutrient Signaling and Growth ControlSemantic proximity Read ↗

Sulfur availability regulates plant growth via glucose-TOR signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.