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Article

Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.

Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2013

Koczor Christopher A, Torres Rebecca A, Fields Earl, Qin Qianhong, Park Jade, Ludaway Tomika, Russ Rodney, Lewis William

Abstract excerpt

Mitochondria produce the energy required for proper cardiac contractile function, and cardiomyocytes that exhibit reduced mitochondrial electron transport will have reduced energy production and decreased contractility. Mitochondrial DNA (mtDNA) encodes the core subunits for the protein complexes of the electron transport chain (ETC). Reduced mtDNA abundance has been linked to reduced ETC and the development of...

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Identifiers

PMID: 23090637
DOI: 10.1038/labinvest.2012.146
PMCID: PMC3556371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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