Article
Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2009
Kohler James J, Cucoranu Ioan, Fields Earl, Green Elgin, He Stanley, Hoying Amy, Russ Rodney, Abuin Allison, Johnson David, Hosseini Seyed H, Raper C Michael, Lewis William
Abstract excerpt
Transgenic mice (TG) were used to define mitochondrial oxidative stress and cardiomyopathy (CM) induced by zidovudine (AZT), an antiretroviral used to treat HIV/AIDS. Genetically engineered mice either depleted or overexpressed mitochondrial superoxide dismutase (SOD2(+/-) KOs and SOD2-OX, respectively) or expressed mitochondrially targeted catalase (mCAT). TGs and wild-type (WT) littermates were treated (oral...
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