Article
Similarity in recombination rate and linkage disequilibrium at CYP2C and CYP2D cytochrome P450 gene regions among Europeans indicates signs of selection and no advantage of using tagSNPs in population isolates.
Pharmacogenetics and genomics - 1 Dec 2012
Pimenoff Ville N, Laval Guillaume, Comas David, Palo Jukka U, Gut Ivo, Cann Howard, Excoffier Laurent, Sajantila Antti
Abstract excerpt
OBJECTIVE: Linkage disequilibrium (LD) and recombination rate variations are known to vary considerably between human genome regions and populations mostly because of the combined effects of mutation, recombination, and demographic history. Thus, the pattern of LD is a key issue to disentangle variants associated with complex traits. Here, we aim to describe the haplotype structure and LD variation at the...
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