Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuating Mutations in nsP1 Reveal Tissue-Specific Mechanisms for Control of Ross River Virus Infection

16 Jan 2014

Abstract excerpt

UNLABELLED: Ross River virus (RRV) is one of a group of mosquito-transmitted alphaviruses that cause debilitating, and often chronic, musculoskeletal disease in humans. Previously, we reported that replacement of the nonstructural protein 1 (nsP1) gene of the mouse-virulent RRV strain T48 with that from the mouse-avirulent strain DC5692 generated a virus that was attenuated in a mouse model of disease. Here we...

Source

Identifiers

PMID: 24429363
DOI: 10.1128/jvi.02609-13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuating Mutations in nsP1 Reveal Tissue-Specific Mechanisms for Control of Ross River Virus InfectionPMID 24429363Read ↗

Mutations in nsP1 and PE2 are critical determinants of Ross River virus-induced musculoskeletal inflammatory disease in a mouse model.Semantic proximity Read ↗

Plasmacytoid Dendritic Cells Mediate Control of Ross River Virus Infection via a Type I Interferon-Dependent, MAVS-Independent Mechanism.Semantic proximity Read ↗

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAsSemantic proximity Read ↗

Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus.Semantic proximity Read ↗

An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.Semantic proximity Read ↗

The Molecular and Cellular Aspects of Arthritis Due to Alphavirus InfectionsSemantic proximity Read ↗

Naturally occurring N-terminal mutations in SARS-CoV-2 nsp1 impact innate immune modulation but do not affect virus virulenceSemantic proximity Read ↗

An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis.Semantic proximity Read ↗

Species-Specific Contribution of the Four C-Terminal Amino Acids of Influenza A Virus NS1 Protein to VirulenceSemantic proximity Read ↗

Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in miceSemantic proximity Read ↗

Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.Semantic proximity Read ↗

CD8+ T Cells Control Ross River Virus Infection in Musculoskeletal Tissues of Infected MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.