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Article

Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8+ T Cells.

Frontiers in immunology - 1 Jan 2021

Stein Jens V, Ruef Nora, Wissmann Stefanie

Abstract excerpt

Tissue-resident CD8+ T cells (CD8+ TRM) populate lymphoid and non-lymphoid tissues after infections as first line of defense against re-emerging pathogens. To achieve host protection, CD8+ TRM have developed surveillance strategies that combine dynamic interrogation of pMHC complexes on local stromal and hematopoietic cells with long-term residency. Factors mediating CD8+ TRM residency include CD69, a surface...

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Identifiers

PMID: 33659008
DOI: 10.3389/fimmu.2021.626019
PMCID: PMC7917134

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