A Hierarchical Network of Four Regulatory Genes Controlling Production of the Polyene Antibiotic Candicidin inStreptomycessp. Strain FR-008

Abstract excerpt

The regulation of antibiotic biosynthesis byStreptomycesspecies is complex, especially for biosynthetic gene clusters with multiple regulatory genes. The biosynthetic gene cluster for the polyene antibiotic candicidin contains four consecutive regulatory genes, which encode regulatory proteins from different families and which form a subcluster within the larger biosynthetic gene cluster inStreptomycessp. FR-008....

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