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Article

The effect of alpha-v integrin inhibition on the malignant characteristics of medulloblastoma.

Journal of neurosurgery. Pediatrics - 1 Jan 2013

Thompson Eric M, Whitney Nathaniel L, Wu Y Jeffrey, Neuwelt Edward A

Abstract excerpt

OBJECT: Hypoxia induces an aggressive phenotype in some brain tumors in part due to hypoxia-inducible factor-1α (HIF-1α) and integrin expression. The importance of hypoxia in medulloblastoma is unclear and the interaction of HIF-1α and c-Myc in medulloblastoma has not been explored. The objective of this study was to determine if hypoxia induces an aggressive phenotype in human medulloblastoma cells that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23082872
DOI: 10.3171/2012.9.PEDS12268
PMCID: PMC3709582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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