Article
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease.
Nature genetics - 1 Oct 2001
MacDonald T J, Brown K M, LaFleur B, Peterson K, Lawlor C, Chen Y, Packer R J, Cogen P, Stephan D A
Abstract excerpt
Little is known about the genetic regulation of medulloblastoma dissemination, but metastatic medulloblastoma is highly associated with poor outcome. We obtained expression profiles of 23 primary medulloblastomas clinically designated as either metastatic (M+) or non-metastatic (M0) and identified 85 genes whose expression differed significantly between classes. Using a class prediction algorithm based on these...
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