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Article

HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

4 Nov 2010

Abstract excerpt

BACKGROUND: Hypoxia induces activation of the HIF-1 pathway and is an essential characteristic of malignant gliomas. Hypoxia has been linked to tumor progression, therapy resistance and poor prognosis. However, little is known about the impact of HIF-1α inhibition on radioresistance of malignant glioma. METHODS: In this study, we investigated the effects of the inhibition of HIF-1α on cell survival and...

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PMID: 21050481
DOI: 10.1186/1471-2407-10-605

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