Article
Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
PloS one - 1 Jan 2012
Trancikova Alzbeta, Mamais Adamantios, Webber Philip J, Stafa Klodjan, Tsika Elpida, Glauser Liliane, West Andrew B, Bandopadhyay Rina, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase enzymatic domains. Disease-associated mutations in LRRK2 variably influence enzymatic activity w...
Topics
- Adaptor Proteins, Signal Transducing
- Aged
- Aged, 80 and over
- Animals
- Brain
- Carrier Proteins
- Cell Cycle Proteins
- Eukaryotic Initiation Factors
- Female
- HEK293 Cells
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Mammals