Article
Inflammation, stem cells and atherosclerosis genetics.
Current opinion in molecular therapeutics - 1 Dec 2010
Goldschmidt-Clermont Pascal J, Seo David M, Wang Liyong, Beecham Gary W, Liu Zhao Jun, Vazquez-Padron Roberto I, Dong Chunming, Hare Joshua M, Kapiloff Michael S, Bishopric Nanette H, Pericak-Vance Margaret, Vance Jeffery M, Velazquez Omaida C
Abstract excerpt
Atherosclerosis and its associated complications remain the primary cause of death in humans. Aging is the main contributor to atherosclerosis, compared with any other risk factor, yet the specific manner in which age increases risk (the 'aging-risk' mechanism) remains elusive. A novel concept for atherosclerosis risk implicates a lack of endothelial progenitor cell (EPC)-dependent arterial repair in the...
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