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Article

Target-template relationships in protein structure prediction and their effect on the accuracy of thermostability calculations.

Protein science : a publication of the Protein Society - 1 Feb 2023

Lihan Muyun, Lupyan Dmitry, Oehme Daniel

Abstract excerpt

Improving protein thermostability has been a labor- and time-consuming process in industrial applications of protein engineering. Advances in computational approaches have facilitated the development of more efficient strategies to allow the prioritization of stabilizing mutants. Among these is FEP+, a free energy perturbation implementation that uses a thoroughly tested physics-based method to achieve...

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PMID: 36573828
DOI: 10.1002/pro.4557
PMCID: PMC9878467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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