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Article

Accurately Predicting Mutation-Caused Stability Changes from Protein Sequences Using Extreme Gradient Boosting.

Journal of chemical information and modeling - 27 Apr 2020

Lv Xuan, Chen Jianwen, Lu Yutong, Chen Zhiguang, Xiao Nong, Yang Yuedong

Abstract excerpt

Accurately predicting the impact of point mutation on protein stability has crucial roles in protein design and engineering. In this study, we proposed a novel method (BoostDDG) to predict stability changes upon point mutations from protein sequences based on the extreme gradient boosting. We extracted features comprehensively from evolutional information and predicted structures and performed feature selection...

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Identifiers

PMID: 32203653
DOI: 10.1021/acs.jcim.0c00064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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