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Article

Nucleotide Excision Repair and Transcription-coupled DNA Repair Abrogate the Impact of DNA Damage on Transcription.

The Journal of biological chemistry - 8 Jan 2016

Nadkarni Aditi, Burns John A, Gandolfi Alberto, Chowdhury Moinuddin A, Cartularo Laura, Berens Christian, Geacintov Nicholas E, Scicchitano David A

Abstract excerpt

DNA adducts derived from carcinogenic polycyclic aromatic hydrocarbons like benzo[a]pyrene (B[a]P) and benzo[c]phenanthrene (B[c]Ph) impede replication and transcription, resulting in aberrant cell division and gene expression. Global nucleotide excision repair (NER) and transcription-coupled DNA repair (TCR) are among the DNA repair pathways that evolved to maintain genome integrity by removing DNA damage. The...

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Identifiers

PMID: 26559971
DOI: 10.1074/jbc.M115.685271
PMCID: PMC4705403

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