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Article

Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase.

The Journal of biological chemistry - 24 Nov 2006

Hanes Jeremiah W, Thal David M, Johnson Kenneth A

Abstract excerpt

To assess the role of oxidative stress on the replication of mitochondrial DNA, we examined the kinetics of incorporation of 8-oxo-7,8-dihydroguanosine (8-oxodG) triphosphate catalyzed by the human mitochondrial DNA polymerase. Using transient state kinetic methods, we quantified the kinetics of incorporation, excision, and extension beyond a base pair containing 8-oxodG. The 8-oxodGTP was incorporated opposite...

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Identifiers

PMID: 17005553
DOI: 10.1074/jbc.M607965200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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