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RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice

30 Sept 2012

Abstract excerpt

Mitochondrial function declines with age in postmitotic tissues such as brain, heart and skeletal muscle. Despite weekly exercise, aged mice showed substantial losses of mtDNA gene copy numbers and reductions in mtDNA gene transcription and mitobiogenesis signaling in brain and heart. We treated these mice with weekly intravenous injections of recombinant human mitochondrial transcription factor A (rhTFAM)....

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PMID: 23075607
DOI: 10.18632/aging.100488

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