Article
Developing therapeutics for the diseases of protein misfolding.
Neurology - 24 Jan 2006
May Barnaby C H, Govaerts Cedric, Cohen Fred E
Abstract excerpt
Our current structural and biologic understanding of the misfolding diseases has restricted the development of therapies that target these diseases at a molecular level. The prion diseases are illustrative of this group of misfolding disorders and provide a model system for therapeutic intervention. Strategies to inhibit the replication and accumulation of the prion protein are being developed and have entered...
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