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Article

Regulation of the Growth of Multinucleated Muscle Cells by an Nfatc2-Dependent Pathway

16 Apr 2001

Abstract excerpt

The nuclear factor of activated T cells (NFAT) family of transcription factors regulates the development and differentiation of several tissue types. Here, we examine the role of NFATC2 in skeletal muscle by analyzing adult NFATC2(-/)- mice. These mice exhibit reduced muscle size due to a decrease in myofiber cross-sectional area, suggesting that growth is blunted. Muscle growth was examined during regeneration...

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PMID: 11309414
DOI: 10.1083/jcb.153.2.329

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